Cetuximab is used to treat certain types of head and neck cancer, and colorectal cancer. Learn how the medication is given, its common side effects, special precautions to watch out for, and more.

What is this medication for?

Cetuximab is a targeted medication used to treat certain types of head and neck cancer, and colorectal cancer. It works by binding to a protein called epidermal growth factor receptor (EGFR) on cancer cells, blocking the cancer cells’ ability to grow.

How should I take or use this medication?

Cetuximab is injected into the vein (given intravenously) as an infusion (drip).

What precautions should I take when taking or using this medication?

Inform your healthcare professional if: 

• You are allergic to this medication or any of the other ingredients of this medication
• You are pregnant, planning to become pregnant, or breastfeeding 
  • Female patients who may become pregnant should use effective birth control during treatment and for 2 months after their last treatment.
  • Do not breastfeed during treatment and for 2 months after your last dose.
• You are taking any other medications, including supplements, traditional medications and herbal remedies. 

What are some common side effects of this medication?

• Skin rashes that look like acne (pimples), usually occurring over the face, chest and back. Rash may also be itchy.
  • Protect yourself from the sun by using sunscreen, wearing long-sleeved clothes and long pants, and avoid spending time directly under the sun.
  • Use moisturizer regularly to prevent dry skin.
• Nail changes, increased risk of nail infections. This may appear as redness, swelling or tenderness around the nail bed.
  • Keep nails short and avoid prolonged contact with water and harsh detergents.
• Changes to hair texture
  • May also affect facial hair and eyelashes.
• Mouth ulcers
  • Avoid eating hard or spicy foods.
  • Brush teeth with a soft-bristled toothbrush.
  • Use a non-alcohol-containing mouthwash to maintain mouth hygiene after meals.
• Diarrhea or constipation
  • To manage diarrhea:
    • Drink more water or clear fluids to replace the fluids lost.
    • Avoid oily, spicy food or dairy products.
  • To manage constipation:
    • Drink more water or clear fluids (if you do not have a limit on the amount of water you can drink each day).
• Low magnesium levels (a type of mineral needed by the body). Some people may have symptoms such as muscle cramps, weakness, numbness and tingling, while some people may not experience any symptoms at all.

What are some rare but serious side-effects that I need to seek medical advice immediately?

• Infusion reaction, which is an allergic reaction that happens during the infusion. Symptoms include one or more of the following:
  • Fever, chills or shivering
  • Difficulty breathing
  • Feeling dizzy or lightheaded
  • Itchy rashes
  • Swollen face/eyes/lips/tongue
• Symptoms of lung problems such as a dry cough that doesn’t go away and feeling breathless
• Severe skin rashes affecting a large area of the body or causing pain and blistering
• Severe diarrhea (more than 4 times a day)

If you experience any of these symptoms, you should see your healthcare professional immediately.

What food or medication should I avoid when I take or use this medication?

Avoid taking traditional Chinese medications (TCM) or “jamu” when you are on this medication.

Disclaimer

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on October 2023