Medication Information Leaflet
Class of Diabetes Medications | How it works | How to take the medication | What to take note of |
Biguanides eg. Metformin (Glucophage®) | Helps the body to use insulin more effectively and decrease the amount of sugar made by the liver | Take the medication tablet(s) with meals or after meals to reduce stomach side effects. | The medication may cause:
This should get better with time after your body gets used to this medication. Inform your doctor if you will need an examination involving the injection of a dye or contrast or if you are going for any major surgery. You may need to stop taking this medication for a certain time before and after the examination or the surgery. |
Sulphonylureas eg.
| Helps your pancreas to release more insulin | Take the medication tablet(s) immediately before meals. Do not miss or delay meals. Otherwise, your blood sugar level may fall too low. | This medication may cause weight gain. Inform your doctor if you have a genetic condition called Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency, a genetic condition in which your red blood cells break down faster than they are made. Alcohol can affect some of these medications. Check with your pharmacist if you are planning to drink alcohol. For example, having alcohol with chlorpropamide increases the risk of side effects like facial flushing and vomiting. |
Dipeptidyl peptidase-4 (DPP-4) inhibitors eg. Linagliptin (Trajenta®) Sitagliptin (Januvia®) Vildagliptin (Galvus®) Saxagliptin (Onglyza®) | Helps to increase insulin release after a meal and reduce the amount of sugar made by your liver | Take the medication before food or after food. | Inform your doctor immediately if you have severe stomach pain that does not go away. This could be a sign of the inflammation of the pancreas, a condition known as pancreatitis. Other symptoms include:
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Sodium-glucose co-transporter-2 (SGLT2) inhibitors eg. Dapagliflozin (Forxiga®) Empagliflozin (Jardiance®) Canagliflozin (Invokana®) | Prevent the kidneys from reabsorbing sugar (glucose) back into the blood, hence increasing the amount of sugar that is removed in the urine | Take the medication before food or after food. | This medication may cause genital and urinary tract infections. This can be prevented by maintaining good genital hygiene. This medication may cause low blood pressure and result in giddiness. You can prevent this by getting up from a sitting or lying position slowly. Stop the medication and inform your doctor immediately if you experience:
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a-glucosidase inhibitors eg. Acarbose (Glucobay®) | It works by slowing down the breakdown of carbohydrates from our diet to simple sugars. Carbohydrates are a type of nutrient found in starchy foods such as bread, noodles, potatoes and rice. This slows down the absorption of sugar and the quick rise of your blood sugars. | Take the medication immediately before or with the first mouthful of food. | This medication may cause:
This should get better with time after your body gets used to this medication. |
Meglitinides eg. Repaglinide (Novonorm®) | Help your pancreas to release more insulin | Take the medication immediately before meals. Do not miss or delay meals. Otherwise, your blood sugar level may fall too low. | |
Thiazolidinediones eg. - Pioglitazone (Actos®) | Makes your body more sensitive and responsive to the effects of insulin. Insulin helps to control the level of blood sugar in your body. | Take the medication before food or after food. | Inform your healthcare professional if you have any heart condition. Inform your healthcare professional if you have had a fall more than once in the past year as this medication can increase the chances of broken bones. |
Please visit www.moh.gov.sg/knowyourmeds and www.ndf.gov.sg for more information on medication.
Last updated on May 2023
This article was last reviewed on Wednesday, June 28, 2023