Topical non-steroidal anti-inflammatory drugs are used to treat pain and reduce inflammation. Learn how to use these medications, their common side effects, precautions to watch out for, and more.

What is this medication for?

Topical non-steroidal anti-inflammatory drugs (NSAIDs) are a group of medications commonly used to treat pain and reduce inflammation. They are commonly used for muscle and joint pain or swelling. They are available as either a gel, cream or patch.

Examples of topical NSAIDs available without requiring a prescription include Diclofenac, Flurbiprofen, Ketoprofen and Piroxicam.

How should I take or use this medication?

• For creams or gels, apply a thin layer on the affected area and gently rub it into the skin according to the labelled instructions.
• For plasters, apply 1 plaster on the affected area as required according to the labelled instructions. The plasters are not waterproof. Do not exceed the frequency of use recommended by the manufacturer.
• Do not apply BOTH the cream or gel and the plaster on the same area of skin.
• Avoid applying the medication on irritated or broken skin and areas near the eyes, mouth, nose and genitals.
• Avoid exposing the treated area where you applied the gel to too much sunlight.

What should I do if I forget to take or use this medication?

As topical NSAIDs are used when needed to relieve pain and swelling, it is not necessary to apply it on a fixed schedule. Please check with your healthcare professional if you are unsure.

What precautions should I take when taking or using this medication?

Inform your healthcare professional if:

• You are allergic to NSAIDs or any other ingredients used in these medications, sunblocks or perfumes.
• You are pregnant, planning to become pregnant or breastfeeding.
• You have a history of photosensitivity reactions (redness and inflammation of sun-exposed skin).

Do not use any airtight bandage or dressing over the area of application. This may increase the risk of side effects.

If you do not experience improvement in pain or it worsens after 7 days of treatment, your condition may be too serious for self-treatment and you should consult a healthcare professional.

What are some common side effects of this medication?

• Topical NSAIDs are usually well-tolerated. Common side effects may include mild redness and irritation at the area on which the medication is applied. 
  • These side effects are usually mild and go away after some time. However, if the symptoms are bothersome, do not go away or become worse, stop these medications and consult your healthcare professional.

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body
• The area which the medication is applied to appears itchy, swollen and blistering following exposure to the sun

If you experience any of these symptoms, you should stop these medications and see your doctor immediately.

What food or medication should I avoid when I take or use this medication?

Avoid using more than one topical medication on the same area of skin when using these medications.

How should I store this medication?

Store in a cool and dry place away from direct sunlight. Keep these medications away from children.

How do I throw away this medication safely?

Pack these medications into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.

Disclaimer

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist. 

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information. 

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on August 2024